Test solution— Accurately weigh about 65 mg of Hypromellose Acetate Succinate into a 5-mL reaction vial, and add 2.0 mL of o-xylene and about 100 mg of adipic acid. Add 2.0 mL of Hydriodic acid, and close the vial tightly with a cap.
Hypromellose is a non-toxic material which has been used in pharmaceutical, food, and cosmetic industries for many years. Based on Hypromellose, acetyl and succinoyl groups are introduced to the hydroxyl groups of the backbone, and this constitutes Shin-Etsu AQOAT ®, Hypromellose Acetate Succinate (HPMCAS).
Hypromellose acetate succinate also forms a clear or turbid solution in buffers of pH greater than 4.5 with the rank order of solubility for the various grades increasing with …
Hydroxypropyl methylcellulose acetate succinate: potential drug-excipient incompatibility. In this case, the hot-melt extrusion (HME) product prepared from HPMC-AS and our model compound (compound A) was tested after heating at 140 degrees C up to 5 h. The succinate esters of compound A and its epimer were found in the product,.
LogP 5.66 4.5 4.83 pKa1 3.70 (weak base) 9 (weak acid) Neutral Solubility (mg/l) <1 8 19.7
Hypromellose meets USP testing specifications Synonym: (Hydroxypropyl) methyl cellulose, Hydroxypropylmethylcellulose 2910 CAS Number 9004-65-3. MDL number MFCD00131360
based on hydroxypropyl methylcellulose acetate succinate (HPMCAS).47,48 Such "spray-dried dispersions" (SDDs) accomplish the following objectives: (1) enhance the oral absorption of poorly water-soluble compounds by attaining and sustaining a supersaturated concentration of drug in the
Aug 29, 2008· Type L HPMC-AS represents polymer with high ratio of succinoyl substitution to acetyl substitution (S/A ratio), while type H with a low S/A ratio and type M with a medium S/A ratio. With a high S/A ratio, type L HPMC-AS dissolves at a lower pH (≥5.5), compared with pH ≥ 6.0 for type M and pH ≥ 6.8 for type H .
Hypromellose (), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used as eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commercial products.. As a food additive, hypromellose is an emulsifier, thickening and suspending agent, and an alternative to animal gelatin.
* Disclaimer: The Harmonized System (HS) code provided on this webpage are for information purposes only and are subject to change without notice.